Multi-Objective Deep Reinforcement Learning for Personalized Dose Optimization Based on Multi-Indicator Experience Replay

نویسندگان

چکیده

Chemotherapy as an effective method is now widely used to treat various types of malignant tumors. With advances in medicine and drug dosimetry, the precise dose adjustment chemotherapy drugs has become a significant challenge. Several academics have investigated this problem depth. However, these studies concentrated on efficiency cancer treatment while ignoring other bodily indicators patient, which could cause complications. Therefore, handle above problem, research creatively proposes multi-objective deep reinforcement learning. First, order balance competing indications inside optimization process give each indicator better outcome, we propose multi-criteria decision-making strategy based integration concept. In addition, provide novel multi-indicator experience replay for learning, significantly speeds up learning compared conventional approaches. By modeling body our approach simulate The experimental results demonstrate that plan generated by can contradiction between tumor’s effect biochemical than plans, its time only one-third use.

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ژورنال

عنوان ژورنال: Applied sciences

سال: 2022

ISSN: ['2076-3417']

DOI: https://doi.org/10.3390/app13010325